GCC2019 has ended
The 2019 Galaxy Community Conference (GCC2019) was held in Freiburg, Germany, 1-8 July.  There was one day of training, three days of mixed meeting and training, and then two to four days of CollaborationFest.  The meeting featured joint & parallel sessions; invited, accepted, and lightning talks; poster and demo sessions; birds-of-a-feather meetups; social events; and training sessions every day.

Thanks to everyone who helped make GCC2019 a success!

Claudia Isabelle Keller Valsecchi

Max-Planck Institute of Immunobiology and Epigenetics
Reconstitution of the Dosage Compensation Complex
Keller1, C. I., Hallacli1, E., Akhtar1, A.

1Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany


Genetic information can be epigenetically modified independently of the DNA sequence itself. These chromatin-based regulatory mechanisms play a fundamental role in many biological processes, for example, differentiation and development. Despite recent advances in mapping epigenetic states genome-wide, a mechanistic understanding of how they affect gene expression and the transcription machinery is missing. During Dosage Compensation (DC), the expression of the X chromosome is equalized between females (XX) and males (XY). As DC operates independently of the DNA sequence, it provides an ideal system to study transcriptional regulation by epigenetic mechanisms. In Drosophila, DC operates on the male X by histone acetylation and recruitment of the MSL complex.

We are interested in mechanistically dissecting, how the MSL complex affects transcription. For this, we are working on producing a fully recombinant MSL complex. Our final goal is to study Dosage Compensation and its components individually in an in vitro system. Our latest progress will be presented at the meeting.

HFSP Long-Term Fellow (Award year 2014)
Fellow: KELLER, Claudia
Host supervisor: AKHTAR, Asifa